Material Safety Data Sheet for 2-(2-Aminoethylamino)Ethanol (AEEA)

Identification

Chemical Name: 2-(2-Aminoethylamino)ethanol
Synonyms: AEEA, Aminoethylethanolamine
CAS Number: 111-41-1
Recommended Uses: Intermediate in synthesis of pharmaceuticals, surfactants, and corrosion inhibitors; component in gas treating solutions
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Hazard Identification

GHS Classification: Acute toxicity (oral): Category 4; Skin corrosion/irritation: Category 1B; Serious eye irritation: Category 2A; Specific target organ toxicity (single exposure): Category 3 (Respiratory tract irritation)
Signal Word: Danger
Hazard Statements: Harmful if swallowed; causes severe skin burns and eye damage; may cause respiratory irritation
Pictograms: Corrosive, Exclamation mark
Precautionary Statements: Avoid breathing vapors/mist; wash hands thoroughly after handling; wear protective gloves/clothing/eye and face protection; IF SWALLOWED: Rinse mouth. Do NOT induce vomiting; IF INHALED: Remove person to fresh air and keep comfortable for breathing.
Other Hazards: Prolonged exposure may cause burns or dermatitis; can release toxic vapors on decomposition.

Composition / Information on Ingredients

Substance: 2-(2-Aminoethylamino)ethanol
CAS Number: 111-41-1
Concentration: 100% (pure substance)
Impurities/Additives: Trace amounts of related amines and possible water (up to 0.5%)

First Aid Measures

Inhalation: Remove to fresh air, support breathing as needed, seek medical advice if symptoms persist.
Skin Contact: Remove contaminated clothing; wash affected area with soap and plenty of water for at least 15 minutes; get medical attention for irritation or burning sensation.
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses, continue rinsing for at least 15 minutes; seek immediate medical attention.
Ingestion: Rinse mouth thoroughly, do not induce vomiting, never give anything by mouth to an unconscious person, seek immediate medical attention.
Most Important Symptoms/Effects: Burning pain, irritation, tissue damage to skin and eyes, cough, nausea
Notes for Physicians: Treat symptomatically, monitor for respiratory distress, possible endoscopic examination for ingestion cases

Fire-Fighting Measures

Suitable Extinguishing Media: Water fog, foam, carbon dioxide (CO2), dry chemical
Unsuitable Extinguishing Media: High-pressure water jets
Special Hazards: Can release toxic fumes, including nitrogen oxides, ammonia, and carbon monoxide during combustion
Protective Equipment for Firefighters: Self-contained breathing apparatus (SCBA), full protective suit recommended
Firefighting Procedures: Move containers from area if possible, cool containers with water spray, prevent contaminated runoff from entering drains and watercourses

Accidental Release Measures

Personal Precautions: Avoid contact with eyes, skin, and clothing; ensure proper ventilation; remove ignition sources
Protective Equipment: Chemical resistant gloves, safety goggles, face shield, chemical apron or protective clothing
Environmental Precautions: Prevent entry into sewers, surface water, or soil
Methods for Cleanup: Absorb with inert material (sand, earth), collect in labeled containers for disposal, ventilate area, wash spill site with large amounts of water
Small Spills: Wipe up and neutralize with dilute acetic acid
Large Spills: Evacuate area, contain with dikes or absorbent barriers

Handling and Storage

Precautions for Safe Handling: Use only with adequate ventilation; avoid breathing vapor, mist, or spray; avoid contact with skin, eyes, and clothing; wash hands thoroughly after use
Conditions for Safe Storage: Store in tightly-closed containers, away from acids, oxidizers, and strong reducing agents; keep in a cool, dry, well-ventilated place; segregate from foodstuffs and incompatible materials
Incompatible Materials: Strong acids, acid chlorides, acid anhydrides, oxidizers; may react violently
Minimum Storage Temperature: Not below 0°C (32°F), protect from freezing
Other Considerations: Inspect containers regularly for leaks or corrosion

Exposure Controls and Personal Protection

Occupational Exposure Limits: No official U.S. OSHA PEL or ACGIH TLV; supplier recommends TWA 1 ppm (4.2 mg/m³) as good practice
Engineering Controls: Use closed systems, local exhaust and general ventilation to prevent vapor buildup
Personal Protective Equipment: Gloves: Nitrile, neoprene, or butyl rubber; Eye: Chemical safety goggles or face shield; Skin: Chemical resistant apron or full-body suit for extensive exposure; Respiratory: Approved air-purifying respirator if ventilation is inadequate or exposure limits are exceeded
Hygiene Measures: Remove contaminated clothing, wash thoroughly after handling, prohibit eating, drinking or smoking in handling area

Physical and Chemical Properties

Appearance: Colorless to pale yellow liquid
Odor: Ammonia-like, strong
Odor Threshold: Not determined
pH: 11-12 (aqueous solution, 10%)
Melting Point/Freezing Point: 13°C (55°F)
Boiling Point: 243°C (469°F)
Flash Point: 130°C (266°F) (closed cup)
Evaporation Rate: Negligible at room temperature
Flammability: Not highly flammable; combustible
Upper/Lower Flammability or Explosive Limits: Not determined
Vapor Pressure: 0.02 mmHg at 25°C
Vapor Density: 3.2 (Air = 1)
Relative Density: 1.03 g/cm³ at 20°C
Solubility in Water: Completely miscible
Partition Coefficient (n-octanol/water): Log Kow: -1.46
Auto-Ignition Temperature: 355°C (671°F)
Decomposition Temperature: Not determined
Viscosity: 53 mPa.s at 25°C

Stability and Reactivity

Chemical Stability: Stable under standard conditions and recommended storage
Reactivity: Reacts exothermically with acids; can generate heat with chlorinating agents and oxidizing agents; risk of violent reactions with certain chemicals such as acid chlorides and anhydrides
Hazardous Reactions: Risk of polymerization is low, but hazardous decomposition possible above 200°C (formation of toxic gases)
Conditions to Avoid: High heat, open flames, incompatible reactants
Incompatible Materials: Strong acids, oxidizers, acid chlorides, acid anhydrides, copper, and aluminum (corrosive to metals)
Hazardous Decomposition Products: Ammonia, nitrogen oxides, carbon monoxide, carbon dioxide

Toxicological Information

Acute Toxicity: Oral LD50 (Rat): 300-2000 mg/kg; Dermal LD50 (Rabbit): >2000 mg/kg; inhalation toxicity data limited but expected to be moderate
Skin Corrosion/Irritation: Causes severe burns; prolonged or repeated contact can result in dermatitis
Serious Eye Damage/Eye Irritation: Causes serious eye damage, possible permanent injury
Respiratory Sensitization: May cause respiratory tract irritation, coughing, and shortness of breath
Skin Sensitization: Not a known skin sensitizer
Chronic Toxicity: Prolonged exposure may affect liver and kidneys
Mutagenicity/Carcinogenicity/Reproductive Toxicity: No data indicating mutagenic or carcinogenic effects; no evidence for reproductive toxicity
Symptoms of Exposure: Burning sensation, coughing, laryngeal spasm, headache, nausea
Routes of Exposure: Inhalation, skin and eye contact, ingestion

Ecological Information

Ecotoxicity: Harmful to aquatic organisms, especially in concentrated form; acute toxicity to fish (LC50, 96h): 146 mg/L (Leuciscus idus); Daphnia (EC50, 48h): 40 mg/L
Persistence and Degradability: Readily biodegradable in water and soil
Bioaccumulative Potential: Low potential, Log Kow < 0
Mobility in Soil: High mobility; dissolves easily and may leach through soil
Other Adverse Effects: Localized pH changes may harm aquatic life if large quantities enter water bodies; waste water treatment plants can process moderate concentrations safely
Environmental Precautions: Prevent bulk releases to environment through use of spill containment and proper disposal practices

Disposal Considerations

Waste Treatment Methods: Dispose of through licensed chemical waste contractor; incineration preferred for bulk amounts
Disposal of Packaging: Triple rinse containers; dispose of per local regulations for chemical waste
Disposal Precautions: Do not pour into sewer, watercourses, or onto soil
European Waste Code: 07 01 01 (wastes from organic chemical processes)
Recommended Removal: Neutralize with dilute acid before disposal, ensure local compliance and documentation
Special Handling: Avoid aerosol generation, at all stages containment is important

Transport Information

UN Number: 2735
UN Proper Shipping Name: Amines, liquid, corrosive, n.o.s. (contains 2-(2-Aminoethylamino)ethanol)
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: II
Labels: Corrosive (Class 8)
Marine Pollutant: Not considered a marine pollutant under IMDG
Special Precautions: Package upright, protect from movement or impact; emergency procedures for spillage must be available
Transport Regulations: Comply with ADR/RID (Europe), IMDG (seaborne), IATA (air) standards

Regulatory Information

OSHA Hazardous Chemical (US): Listed, regulated as corrosive and acutely toxic
EU Classification: Dangerous Substances Directive 67/548/EEC: C - Corrosive; Xn - Harmful
REACH Status (EU): Registered under REACH, subject to supply chain communication
TSCA (US): Listed on the TSCA Inventory
Canadian DSL: Listed
Other Country Inventories: Australia (AICS): Listed; China (IECSC): Listed; Japan (ENCS): Listed; Philippines (PICCS): Listed; Korea (KECI): Listed
SARA Title III (Sections 302/304, 311/312): Acute health hazard
California Proposition 65: Not listed
Label Requirements: Corrosive hazard, must be labeled according to current GHS/CLP and local regulations
Workplace Safety Training: All handlers require chemical safety and emergency response training to comply with local occupational requirements