MSDS for Mannitol

Identification

Product Name: Mannitol
Chemical Formula: C6H14O6
Synonyms: D-Mannitol, Mannite, Manna Sugar
CAS Number: 69-65-8
Recommended Use: Pharmaceutical excipient, food sweetener, laboratory reagent
Manufacturer Info: Supplier contact details appear on supplier-issued documents.

Hazard Identification

GHS Classification: This substance does not meet the criteria for classification as hazardous as defined by OSHA Hazard Communication Standard.
Physical Hazards: Dust formation may cause mechanical irritation.
Health Hazards: Inhalation or contact with large quantities may provoke mild irritation to respiratory tract, skin or eyes.
Environmental Hazards: No known major environmental dangers associated with release of mannitol.
Label Elements: Signal word not required, hazard pictogram not required.

Composition / Information on Ingredients

Chemical Name: Mannitol
CAS Number: 69-65-8
EC Number: 200-711-8
Concentration: 99% or greater
Impurities and Stabilizers: Commercial product specifications may include trace levels of related sugars and moisture, depending on storage and handling.

First Aid Measures

Inhalation: Move exposed person to fresh air, seek medical attention if persistent coughing or breathing discomfort occurs.
Skin Contact: Rinse off exposed skin with soap and plenty of water, remove contaminated clothing and launder before reuse.
Eye Contact: Immediately flush eyes with clean, gently flowing water for at least fifteen minutes, and get medical advice if irritation continues.
Ingestion: Rinse mouth, give water to drink if conscious, and consult a health professional if large quantities were swallowed or if symptoms develop.
Note to Physicians: Treatment should address symptoms; no specific antidote is known for mannitol exposure.

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, foam, dry chemical, or carbon dioxide for small fires involving mannitol.
Specific Hazards: During fires, thermal decomposition can release irritating fumes like carbon monoxide and carbon dioxide.
Special Protective Equipment: Wear self-contained breathing apparatus and full protective gear when handling fires with significant dust, since sugar dusts can form explosive mixtures in air under rare conditions.
Firefighting Procedures: Avoid inhalation of combustion gases, control runoff to prevent environmental contamination.

Accidental Release Measures

Personal Precautions: Use dust mask and protective eyewear when large spills or significant dust could be present, avoid direct contact, ventilate area.
Environmental Precautions: Sweep up without generating dust, collect product for reuse or disposal, and prevent runoff into surface water.
Methods for Clean-up: Use non-sparking tools, sweep up and place in labelled waste container, wash spill area with water if needed.
Disposal: Follow local regulations for disposal, avoid release to drains.

Handling and Storage

Handling: Handle with adequate ventilation, minimize dust formation, avoid breathing dust, and wash hands after handling. Use mechanical exhaust in dusty environments.
Storage Conditions: Store in cool, dry, well-ventilated place, keep container tightly closed to prevent moisture uptake, keep away from incompatible materials like strong oxidizers.
Incompatible Materials: Avoid contact with strong acids, bases, and oxidizing substances to prevent hazardous reactions.
Special Requirements: Protect from humidity and direct sunlight. Use only with clean, dry utensils and containers.

Exposure Controls and Personal Protection

Exposure Limits: Occupational exposure limits for mannitol not established in most jurisdictions; always minimize inhalation of dust.
Engineering Controls: Use local exhaust ventilation or process enclosure to control airborne dust.
Personal Protection:
Respiratory Protection: Dust mask or respirator in areas with significant airborne powder.
Eye Protection: Safety glasses with side shields or chemical splash goggles.
Skin Protection: Lightweight gloves and clean work clothing when handling in bulk.
Hygiene Measures: Always wash hands before eating, drinking, or leaving the workplace.

Physical and Chemical Properties

Appearance: White crystalline powder or granules, odorless and sweet-tasting.
Molecular Weight: 182.17 g/mol
Melting Point: Near 167-170 °C
Boiling Point: No data available (decomposes before boiling)
Solubility: Freely soluble in water, slightly soluble in alcohol
Vapor Pressure: Negligible at room temperature
pH: Neutral (5–7 for 10% aqueous solution)
Flash Point: Not applicable
Autoignition Temperature: Data indicates about 430°C
Odor Threshold: Not relevant—odorless
Other Properties: Low hygroscopicity, stable under recommended storage.

Stability and Reactivity

Chemical Stability: Stable under normal temperatures and recommended storage.
Possibility of Hazardous Reactions: Contact with strong oxidizers can result in exothermic reactions.
Conditions to Avoid: Prolonged exposure to moisture and excessive heat.
Incompatible Materials: Strong acids and oxidizing agents.
Decomposition Products: Heating to decomposition produces carbon oxides.

Toxicological Information

Acute Toxicity: Oral LD50 (rat) is around 13,500 mg/kg, considered practically non-toxic.
Chronic Effects: No evidence of carcinogenic, mutagenic, or teratogenic effects.
Routes of Exposure: Inhalation, ingestion, skin and eye contact.
Health Effects: May cause transient gastrointestinal upset at large doses (osmotic diarrhea); dust may irritate respiratory tract or eyes.
Sensitization: Does not tend to provoke allergic skin reactions.
Medical Conditions Aggravated: None known in typical workplace settings.

Ecological Information

Toxicity to Aquatic Life: Not considered acutely toxic to aquatic organisms.
Persistence and Degradability: Readily biodegradable by microorganisms.
Bioaccumulation Potential: Bioaccumulation does not occur.
Mobility: High solubility in water means runoff can lead to dispersion, but not hazardous to aquatic systems at expected concentrations.
Other Adverse Effects: No significant environmental risks reported.

Disposal Considerations

Waste Disposal: Offer surplus or waste product to authorized contractor for recycling or disposal. Dispose according to local, regional, and national regulations.
Contaminated Packaging: Rinse empty packaging, dispose as controlled solid waste. Avoid discharge to natural water bodies or sewers.
Precautions: Prevent unintended release of large quantities into the environment.

Transport Information

UN Number: Not regulated as dangerous goods by transport agencies (ADR, IMDG, IATA).
Proper Shipping Name: Mannitol
Hazard Class: Not applicable.
Packing Group: Not applicable.
Environmental Hazards: Not a marine pollutant.
Special Transport Precautions: Protect from moisture, strong odors, dust-generating handling.

Regulatory Information

US Regulations: Mannitol appears on the US TSCA Inventory and is generally recognized as safe (GRAS) by the FDA for food and pharmaceutical use.
EU Regulations: Mannitol is listed on EINECS and not classified as hazardous under CLP.
Other International Listings: Listed in Canadian DSL/NDSL, Japanese ENCS, Australian AICS.
Workplace Controls: Not subject to specific workplace exposure limits, but general rules for nuisance dust apply.
Hazard Symbols: None required.
Labelling Requirements: Ingredient list for packaged food or pharmaceutical products must reflect mannitol content.