Material Safety Data Sheet (MSDS): Mannitol - Shandong Tianli Pharmaceutical Co.,Ltd
1. Identification
Product Name: Mannitol
Manufacturer: Shandong Tianli Pharmaceutical Co., Ltd
Address: No. 38 Jiefang South Road, Qufu City, Shandong Province, China
Telephone: +86-537-4438888
Recommended Use: Pharmaceutical excipient, food additive, sweetener
Restrictions on Use: Not intended for non-food or non-pharmaceutical applications
Emergency Contact: Local emergency number or company hotline
2. Hazard Identification
GHS Classification: Not classified as hazardous under GHS criteria
Signal Word: None
Hazard Statements: No significant hazard under normal use conditions
Pictograms: None
Precautionary Statements: Avoid excessive dust, ensure adequate ventilation during processing
Health Effects: Mild gastrointestinal discomfort if consumed in large amounts
3. Composition / Information on Ingredients
Chemical Name: Mannitol
Synonyms: D-Mannitol, Mannite, Osmitrol
CAS Number: 69-65-8
EC Number: 200-711-8
Concentration: ≥ 99.0% Mannitol
Impurities or Stabilizing Additives: Water <0.5%, other sugars <0.5%
4. First Aid Measures
Inhalation: Move to fresh air, rinse nose and mouth with water, seek medical attention for respiratory symptoms
Skin Contact: Wash with soap and water, remove contaminated clothing, seek care for persistent irritation
Eye Contact: Rinse with plenty of water for several minutes, remove contact lenses if present, consult physician if irritation develops
Ingestion: Rinse mouth, drink water if conscious, monitor for abdominal discomfort, get medical advice for significant ingestion
5. Fire-Fighting Measures
Suitable Extinguishing Media: Water spray, foam, carbon dioxide, dry powder
Unsuitable Media: Do not use high-pressure water jets
Special Hazards: Combustion may produce carbon monoxide and carbon dioxide
Protective Equipment: Firefighters wear self-contained breathing apparatus and full protective gear
Explosion Risk: Fine dust can form explosive mixtures with air in confined spaces
6. Accidental Release Measures
Personal Precautions: Avoid dust formation, use personal protective equipment
Environmental Precautions: Prevent larger spills from entering drains or waterways
Cleaning Procedures: Use non-sparking tools, sweep up, avoid generating airborne dust, dispose in sealed containers
Emergency Procedures: Evacuate area for large spills, ventilate affected space
7. Handling and Storage
Precautions for Safe Handling: Minimize dust generation, keep containers tightly closed, avoid contact with eyes, wash hands after use
Storage Conditions: Store in cool, dry, well-ventilated location, away from heat, sparks, and open flames
Incompatible Materials: Strong oxidizers
Safe Storage Container: Use moisture-proof packaging, label clearly
Specific End Uses: Industrial, food, and pharmaceutical applications
8. Exposure Controls and Personal Protection
Occupational Exposure Limits: No specific limits set for mannitol; follow general dust exposure limits (e.g., OSHA PEL: 15 mg/m3 total dust)
Engineering Controls: Use local exhaust ventilation to control dust
Personal Protective Equipment: Dust mask, safety glasses, gloves preferred for bulk handling
Hygiene Measures: Wash thoroughly after handling, do not eat or drink near open product
Environmental Exposure Controls: Prevent release to environment through good containment and housekeeping
9. Physical and Chemical Properties
Appearance: White, crystalline powder or granules
Odor: Odorless
pH: Neutral (5.0–7.0 in aqueous solution)
Melting Point: 164–169°C
Boiling Point: Not applicable (decomposes on heating)
Flash Point: Not flammable
Solubility: Soluble in water (21.6 g/100 mL at 25°C), slightly soluble in alcohol
Vapor Pressure: Not volatile at ambient conditions
Partition Coefficient: log Pow -3.1
Density: 1.52 g/cm3
Other Properties: Stable under storage, non-hygroscopic
10. Stability and Reactivity
Chemical Stability: Remains stable under recommended storage and handling conditions
Reactivity: Non-reactive with most common substances
Hazardous Reactions: None under normal use
Conditions to Avoid: Excessive heat, moisture, strong oxidizers
Decomposition Products: Carbon oxides formed at high temperatures
11. Toxicological Information
Acute Toxicity: Ingestion considered low toxicity (LD50 oral, rat: 13,500 mg/kg)
Skin Irritation: Not expected under normal use
Eye Irritation: Dust may cause mild, transient discomfort
Inhalation: Large amounts of airborne dust may cause mechanical irritation
Chronic Effects: No evidence of reproductive or carcinogenic effects has been found
Sensitization: No data suggesting skin or respiratory sensitization in humans
Other Information: Ingesting large quantities can cause osmotic diarrhea, especially in sensitive individuals
12. Ecological Information
Ecotoxicity: Low toxicity to aquatic organisms, expected to degrade easily
Persistence and Degradability: Biodegrades rapidly in soil and water
Bioaccumulation Potential: Low likelihood; not expected to accumulate
Mobility in Soil: High water solubility, likely to disperse if released
Other Adverse Effects: No known significant environmental hazards
13. Disposal Considerations
Waste Treatment Methods: Dispose through authorized waste management company
Product Waste: May be landfilled or incinerated under local regulations
Packaging Disposal: Clean, empty containers can be recycled or disposed in line with national guidelines
Precautions: Avoid release of large amounts into sewer or water systems
14. Transport Information
UN Number: Not regulated
UN Proper Shipping Name: Not regulated
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Special Precautions for Transportation: Keep dry during shipment, avoid rupturing containers, handle as non-hazardous cargo
15. Regulatory Information
Regulatory Status: Approved as GRAS (Generally Recognized As Safe) by US FDA for food use
EU Regulations: Listed in Regulation (EC) No 1333/2008, food additive (E421)
TSCA: Listed
REACH Registration Number: Exempt, food additive
Other National Inventories: Registered in Japan, China, Australia, Canada
Labelling Requirements: Not required for hazard symbols or warnings in major jurisdictions for normal consumer use
