Material Safety Data Sheet: Trehalose – Shandong Tianli Pharmaceutical Co., Ltd
Identification
Product Name: Trehalose
Company: Shandong Tianli Pharmaceutical Co., Ltd
Address: No.1 Tianning Road, Economic Development Zone, Qufu, Shandong, China
Telephone: +86-537-3146796
Synonyms: α,α-Trehalose, Tremalose, Mycose
Recommended Use: Food additive, pharmaceutical ingredient, cosmetic stabilizer, chemical intermediate
CAS Number: 99-20-7
Emergency Contact: +86-537-3146796 (24 hours service)
Hazard Identification
Classification: Not classified as hazardous under GHS guidelines
Label Elements: No pictogram, signal word, or hazard statements required
Risk of Exposure: Slight eye and respiratory irritation possible from dust
Intended Use Precautions: Handle bulk powder with proper ventilation; avoid creating or inhaling dust
Environmental Hazards: No acute or chronic hazards to water, soil, or air identified in standard studies
Other Hazards: No evidence of carcinogenic, mutagenic, or reproductive toxicity
Composition / Information on Ingredients
Chemical Identity: Trehalose
Chemical Formula: C12H22O11
Content: 99% or higher by weight
Impurities: Water (<1.0%), other sugars (<0.5%), ash (<0.05%)
Type: Non-reducing disaccharide
Relevant Excipients: None (pure substance)
First Aid Measures
Inhalation: Move person to fresh air, keep at rest, seek medical advice if symptoms persist
Skin Contact: Wash with soap and water; remove contaminated clothing if necessary
Eye Contact: Rinse cautiously with water for at least 15 minutes; consult physician if irritation remains
Ingestion: Rinse mouth with water, seek medical attention only if discomfort continues
Most Significant Symptoms: Mild local irritation possible after high exposure to dust
Advice to Medical Personnel: Treat symptoms, no known specific antidote
Fire-Fighting Measures
Suitable Extinguishing Agents: Use water spray, dry chemical, carbon dioxide, or foam
Unsuitable Media: High-pressure water jets may spread powder
Fire Hazards: Organic dust may form explosive mixtures with air
Combustion Products: Carbon dioxide, carbon monoxide, water vapor
Protective Equipment: Wear self-contained breathing apparatus and chemical resistant clothing
Advice for Firefighters: Eliminate ignition sources, ventilate area to remove dust
Accidental Release Measures
Personal Precautions: Use protective gloves, goggles, and suitable dust mask; avoid breathing dust and direct contact
Environmental Measures: Prevent large quantities from entering drains; contain with inert absorbent if necessary
Methods for Cleaning Up: Collect powder with non-sparking tools, sweep into suitable containers, wash area with water
Reference to Other Sections: Refer to sections on personal protection and disposal below for further guidance
Handling and Storage
Safe Handling: Ensure use in well-ventilated areas, use local exhaust to minimize airborne particles, minimize powder handling to prevent dust formation, keep away from ignition sources
Hygiene Measures: Wash hands before breaks and after finishing work, remove contaminated clothing promptly
Storage Conditions: Store in tightly sealed containers in a dry, cool, well-ventilated place; keep away from moisture, strong oxidizers
Incompatibles: Strong acids, oxidizing agents
Packaging Materials: Use moisture-proof, food-grade materials for long term stability
Exposure Controls and Personal Protection
Exposure Limits: No occupational exposure limits established by country-specific authorities
Engineering Controls: Use local exhaust ventilation or general room ventilation for bulk powder
Personal Protective Equipment: Protective gloves (nitrile or latex), safety glasses, disposable protective clothing for large scale handling, dust mask (P2 or better) if airborne dust exceeds comfort thresholds
Environmental Controls: Prevent powder release into the environment by good production practice, use dust extraction systems
Physical and Chemical Properties
Appearance: White crystalline or powder form
Odor: Odorless
Odor Threshold: Not applicable
pH (1% solution): 5.0 to 6.5
Melting Point: 203-207°C (decomposition)
Solubility: Soluble in water (68 g/100 mL at 20°C); insoluble in ethanol, ether
Relative Density: 1.58 g/cm³
Bulk Density: 400-650 kg/m³
Vapor Pressure: Negligible at room temperature
Partition Coefficient: Log Pow = -3.7
Other Information: Non-flammable in solution, stable when stored properly
Stability and Reactivity
Stability: Stable under recommended storage and handling conditions
Thermal Decomposition: Begins to decompose over 200°C with production of carbon oxides
Reactivity with Incompatibles: Reacts with strong oxidizing agents, strong acids
Hazardous Polymerization: Will not occur
Conditions to Avoid: Avoid excess moisture, high temperature, strong oxidizers
Hazardous Decomposition Products: Carbon dioxide, carbon monoxide produced during burning
Toxicological Information
Acute Toxicity – Oral: LD50 (rat) > 15,000 mg/kg – no evidence of acute toxicity at likely exposure
Skin Corrosion/Irritation: Non-irritating in animal studies
Eye Irritation: Slight transient irritation possible upon heavy exposure to powder
Respiratory Sensitization: No evidence of allergic or sensitizing potential
Chronic Effects: No indication of mutagenicity, carcinogenicity, or reproductive toxicity based on available studies
Routes of Exposure: Inhalation of dust, eye or skin contact in workplace settings
Other Data: Widely used in food and pharmaceuticals with established safety record
Ecological Information
Ecotoxicity: No significant toxicity to aquatic or terrestrial organisms in typical discharge concentrations
Persistence and Degradability: Readily biodegradable, broken down by microorganisms in soil and water
Bioaccumulative Potential: Not expected to build up in living organisms
Mobility in Soil: Dissolves easily, rapidly diluted and degraded in environmental settings
Other Adverse Effects: No known long-term environmental impacts from normal usage and disposal
Disposal Considerations
Waste Treatment Methods: Dispose as non-hazardous solid waste, observe local regulations
Recommended Disposal: Dilute in water and mix with general wastewater (if permitted); landfill in line with municipal guidelines
Safe Handling of Waste: Use sealed containers to prevent dust emission during transport to disposal
Packaging Disposal: Empty and clean containers may be recycled or disposed with general waste, avoid re-use for food
Transport Information
UN Number: Not regulated for transport
Proper Shipping Name: Trehalose
Class: Not applicable
Packing Group: Not applicable
Transport Hazards: Not considered dangerous for air, sea, rail, or road
Special Precautions: Keep packages dry and sealed during loading, unloading, and storage in transit
Bulk Handling: Large bags or containers require dust control and moisture barrier
Regulatory Information
SDS Regulation: Conforms to China GB/T 16483, U.S. OSHA, European REACH Annex II, and other international standards
Chemical Inventory Status: Listed in China IECSC, US TSCA, EU EINECS
Labelling Requirements: No hazard label required
Restrictions: No specific restrictions apply to industrial or commercial use
Food/Pharma Listings: Approved as GRAS by US FDA; authorized food additive in China, EU, and Japan
Worker Protection: General chemical workplace protections recommended; review collective labor protection laws under local jurisdiction
