Material Safety Data Sheet (MSDS) – Trehalose
Identification
Product Name: Trehalose
Chemical Name: α-D-glucopyranosyl-α-D-glucopyranoside
Synonyms: Mycose, Tremalose
CAS Number: 99-20-7
Recommended Use: Food additive, preservative, stabilizer, pharmaceutical excipient
Supplier: Manufacturer or distributor information provided on container label
Emergency Phone: Local poison control center or emergency response number
Hazard Identification
GHS Classification: Not classified as hazardous
Signal Word: None required
Hazard Statements: Not expected to cause health effects under normal handling
Precautionary Statements: Avoid generating dust, maintain good industrial hygiene
Label Elements: No pictogram or signal word required according to GHS
Other Hazards: Dust may cause slight mechanical irritation to eyes, nose, or throat; no known significant environmental effects; not known to be flammable or reactive under normal conditions
Composition / Information on Ingredients
Chemical: Trehalose
Formula: C12H22O11
Percentage: 100% by weight
Impurities: Trace moisture or manufacturing residues may be present in very minor amounts; not expected to pose significant risk
Molecular Weight: 342.30 g/mol
First Aid Measures
Inhalation: Remove individual to fresh air; rinse nose or throat with water if irritation occurs; seek medical attention if irritation persists
Skin Contact: Wash with soap and plenty of water; remove potentially contaminated clothing; get medical attention if irritation or rash develops
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; keep eye open and continue rinsing; consult doctor if discomfort continues
Ingestion: Rinse mouth thoroughly; drink water to dilute; seek medical attention if symptoms develop or in case of large ingestions or persistent discomfort
Symptoms/Effects: Dust may produce mild irritation to eyes, skin, or respiratory tract
Fire-Fighting Measures
Suitable Extinguishing Media: Water spray, foam, dry powder, or carbon dioxide
Unsuitable Extinguishing Media: None identified under normal conditions
Specific Hazards: Fine dust clouds may pose risk of explosion if ignition source present; decomposition products include carbon dioxide and carbon monoxide
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and suitable protective clothing
Special Fire-Fighting Procedures: Avoid inhaling combustion gases; cool containers with water spray to prevent pressure buildup
Accidental Release Measures
Personal Precautions: Avoid raising dust; use suitable personal protective equipment such as gloves, goggles, and respirators
Environmental Precautions: Prevent large releases from entering drains, sewers, or waterways
Methods for Cleanup: Collect spilled material mechanically; sweep or vacuum up and transfer to provided container for disposal; wash area with water after pickup
Reference to Other Sections: Use proper PPE; refer to handling, disposal, and exposure controls
Handling and Storage
Handling: Handle with care to minimize dust formation; use local exhaust ventilation in dusty conditions; avoid contact with eyes and skin
Hygiene Practices: Wash hands after handling; remove contaminated clothing and wash before reuse
Storage Conditions: Store in a cool, dry, well-ventilated area away from incompatible substances; keep container tightly closed to prevent moisture uptake
Incompatibilities: Avoid strong oxidizing agents; protect from excessive heat and humidity
Exposure Controls and Personal Protection
Occupational Exposure Limits: Not established for trehalose; observe general nuisance dust limits (< 10 mg/m3 total dust)
Engineering Controls: Use local exhaust or general ventilation to control airborne dust levels
Personal Protection:
Respiratory: Dust mask or particulate respirator when high dust conditions expected
Eyes: Safety glasses or goggles
Skin: Gloves and protective clothing if prolonged contact likely
Hygiene Measures: Wash hands and face after use; avoid eating, drinking, or smoking while handling product
Physical and Chemical Properties
Appearance: White crystalline powder or granules
Odor: Odorless
Odor Threshold: Not applicable
pH (solution): Around 5.0–6.5 for 10% aqueous solution
Melting Point: 97–100°C (anhydrous form)
Boiling Point/Range: Decomposes before boiling
Flash Point: Not applicable
Evaporation Rate: Not applicable
Flammability: Not flammable under normal storage and use conditions
Explosion Limits: No data for upper/lower explosion limits
Vapor Pressure: Not volatile
Solubility: Readily soluble in water (68 g/100 mL at 20 °C)
Partition Coefficient (log Kow): Not available
Auto-Ignition Temperature: No data
Decomposition Temperature: >100°C
Viscosity: Not applicable
Stability and Reactivity
Chemical Stability: Stable under normal ambient and anticipated storage conditions
Reactivity: No known dangerous reactions under usual conditions
Incompatible Materials: Strong oxidizing agents
Possibility of Hazardous Reactions: Dust clouds potentially explosive in rare circumstances
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide if burned
Conditions to Avoid: Excessive heat, open flames, ignition sources, high humidity
Toxicological Information
Acute Toxicity: Low toxicity; LD50 (oral, rat) > 15,800 mg/kg
Inhalation: Dust may cause temporary mechanical irritation to respiratory system
Skin Contact: May cause slight irritation with prolonged or repeated exposure
Eye Contact: May cause mild temporary irritation from dust
Ingestion: No harmful effects known from small quantities; not expected to be toxic
Chronic Effects: Not classified as mutagenic, carcinogenic, or reproductively toxic
Sensitization: No evidence of sensitizing effects from available data
Medical Conditions Aggravated by Exposure: Pre-existing respiratory conditions may be aggravated by high dust concentrations
Ecological Information
Aquatic Toxicity: Not expected to harm aquatic organisms due to low solubility and rapid biodegradation
Persistence and Degradability: Biodegradable; microbial and enzymatic processes rapidly convert trehalose to harmless substances
Bioaccumulation: Not expected to bioaccumulate in aquatic or terrestrial organisms
Mobility in Soil: Readily soluble, expected to leach in soil and degrade
Other Adverse Effects: No significant environmental hazards identified
Disposal Considerations
Waste Treatment Methods: Dispose of product and container in accordance with local, regional, and national regulations
Disposal of Product: May be handled as non-hazardous industrial waste; landfill or incinerate in compliance with relevant guidelines
Disposal of Packaging: Rinse and recycle or dispose according to applicable regulations
Special Precautions: Do not release in uncontrolled amounts into drains, watercourses, or soil
Transport Information
UN Number: Not regulated as hazardous for transport
UN Proper Shipping Name: Not classified
Transport Hazard Class(es): No dangerous goods classification
Packing Group: Not assigned
Environmental Hazards: Not environmentally hazardous for transport
Special Precautions for User: Protect from moisture and physical damage during transport
Transport in Bulk: No additional requirements
Regulatory Information
U.S. Regulations: Trehalose is Generally Recognized as Safe (GRAS) for use in food; not listed on SARA, RCRA, CERCLA, or TSCA as hazardous
EU Regulations: Not classified as a hazardous substance under Regulation (EC) No 1272/2008; no specific restrictions on use
Canada: Listed on the Domestic Substances List (DSL), not regulated as hazardous
Global Inventories: Listed on most major chemical inventories
Other Regulatory References: No OELs specifically set; not classified as controlled substance; falls under food additive codes depending on jurisdiction
